The most frequently occuring heteroatoms in heterocycles are nitrogen, oxygen, and sulfur. As selenium containing is very important for the organism, various diseases can result from selenium. The preliminary indications for the successful synthesis of desired compounds iiiviii were the solubility, physical states, and a difference in the melting points mp of benzimidazolium salts and their respective selenium adducts. Many of them have important functions in the human organism. Jul 21, 1998 the present invention improves upon the invention set forth in u. These heterocycles have been applied as antioxidants, cytotoxic agents, apoptosis inducers and chemopreventors, and they possess antidepressant activity, among others. Advances in bio mimetics self assembly nanotechnology. A monte carlo sensitivity analysis of cf 2 and cf radical densities in a cc4f8 plasma. Biologically significant seleniumcontaining heterocycles biologically significant seleniumcontaining heterocycles ninomiya, masayuki. Request pdf recent advances in the chemistry of seleniumcontaining.
Recent advances in the synthesis of biologically relevant. Recent advances in the synthesis of biologically relevant selenium. Qm and qmmm studies on organic and inorganic systems. The heterocyclic compounds with selenium atom in the ring such as. Thick tellurium target preparation by vacuum deposition. Synthesis, characterization, and spectral and biological. This compound has a unique chemical structure and is the first example of a natural heterocyclic compound with a selenoketone derived from. Synthesis and reactions of 2amino4,5,6,7tetrahydro1benzoselenophene3carbonitrile with anticipated biological activity. This article appeared in a journal published by elsevier.
Request pdf seleniumcontaining heterocycles the literature data, mainly of. Abdelhafez et al 2006 phosphorus sulfur and silicon and the related elements 181 2297 crossref. Selenium containing imidazolium salt in designing single. Developments in the chemistry of selenaheterocyclic. Highresolution mass spectroscopy using electrospray ionization esi. Use of hydrazine for the synthesis of 1,3,4selenadiazine derivatives iii.
Seleniumcontaining heterocycles using selenoamides, selenoureas, selenazadienes, and isoselenocyanates, heterocycles, 81, 9. Synthesis of selenoureas and heterocycles based thereon. The most stable tran sition state is itransoid, leading to the p product, and the lowest energy path going to the m product goes through iicisoid, 4. Photophysical properties and excited state dynamics of 4,7dithien2yl2,1,3benzothiad. Biologically significant seleniumcontaining heterocycles. Seleniumcontaining 5membered heterocycles have emerged as an important class of biological compounds. Highlights selenium represents an essential element for organisms. Developments in the chemistry of selenaheterocyclic compounds. The literature data, mainly of the last ten years, on the synthesis, reactions, and practical utilisation of seleniumcontaining heterocycles are analysed, treated systematically, and surveyed. Seleniumcontaining heterocycles from isoselenocyanates.
Therefore, the investigation of new methods for the synthesis of. Advances in bio mimetics free ebook download as pdf file. Unexpected leaving ability of phenyltelluroformates in the presence of internal nucleophiles. Therefore, the investigation of new methods for the synthesis of small seleniumcontaining building. Dec 01, 2011 biologically significant selenium containing heterocycles biologically significant selenium containing heterocycles ninomiya, masayuki. Pdf biologically significant seleniumcontaining heterocycles.
Despite the close association of selenium and sulfur chemistry and biology, the synthesis of organoselenium compounds generally and selenium containing heterocycles more specifically, has scarcely been explored compared to their sulfur containing counterparts. The seleniumcontaining compound in the tuna blood was purified in several chromatographic steps of c18 reverse phase hplc and gel filtration chromatography. The syntheses of azolium salts iiiv and respective senhc adducts viviii were carried out according to our previously reported work. Developments in the chemistry of selenaheterocyclic compounds of.
Jan epsztajn arkivoc 2007 vi 1446 selenonium salts eg. Method for the preparation of free radical pharmaceuticals. Roughly more than one half of all natural products contains heterocyclic components. Complications during alkyl and oxyacyl radical generation in the preparation of sulfur. Foreword this is the seventeenth annual volume of progress in heterocyclic chemistry, which covers the literature published during 2004 on most of the important heterocyclic ring systems. Notably, stabilization of the cationradical center prevents a proton from being expelled. Some of selenaheterocyclic systems containing sete, sep, seb, sezn or sesn bonds which. However, heterocycles with other heteroatoms, such as phosphorus and selenium, also appear. Selenium containing heterocycles from isoselenocyanates. Synthesis and reactions of 2amino4,5,6,7 tetrahydro1benzoselenophene3carbonitrile with anticipated biological. The seleniumcontaining compound was purified from the tuna blood.
Review biologically significant seleniumcontaining heterocycles. Jun 11, 2010 a novel seleniumcontaining compound having a selenium atom in the imidazole ring, 2selenyln. Recent data on the synthesis of various selenoureas and seleniumcontaining heterocycles derived therefrom have been systemized, analyzed, and generalized. This may be attributed to the high toxicity and less stability of many selenium reagents. Synthetic investigation of 3amino2ethylselenopyridine carboxylate using sodium borohydride sh. A large number of original papers concerned with the chemistry, and biology of. In addition, many natural compounds are pharmacologically.
Selenium represents an essential element for organisms as various diseases can result from selenium deficiency. In the past five years, several articles related to the. Zade department of chemical sciences, indian institute of science education and research iiser kolkata, mohanpur 741252, india. Heterocyclic annulated pyridazines continue to attract considerable attention, which mainly arises from the large variety of interesting pharmacological activities, herbicides, insecticides and fungicides. A novel seleniumcontaining compound having a selenium atom in the imidazole ring, 2selenyln. Seleniumcontaining heterocycles 9101112 represent an important family of. Recent advances in the chemistry of seleniumcontaining. The invention provides a method for making a seleniumcarrier conjugate by covalently attaching i an organic selenium compound selected from the group consisting of rseh, rser, rser, rseser and rseser, wherein r and r are each an aliphatic residue containing at least one reactive group selected from the group consisting of aldehyde, amino, alcoholic. As selenium containing is very important for the organism, various diseases can result from selenium deficiency. Despite the close association of selenium and sulfur chemistry and biology, the synthesis of organoselenium compounds generally and seleniumcontaining heterocycles more specifically, has scarcely been explored compared to their sulfurcontaining counterparts.
As a consequence, selenium containing heterocycles are of considerable biochemical and pharmacological relevance. The selenium containing compound in the tuna blood was purified in several chromatographic steps of c18 reverse phase hplc and gel filtration chromatography. Seleniumcontaining heterocycles request pdf researchgate. Thiohydroxamic esters derived from 5benzylseleonpentanoic acid, 6benzylselenohexanoic acid and 7benzylselenoheptanoic acid decompose smoothly upon irradiation, with the loss of carbon dioxide, to give tetrahydroselenophene, selenane and selenopane in good yield. Principles and applications cause distortion of the. Therefore, the investigation of new methods for the synthesis of small selenium containing building. Synthesis of 2,4disubstituted thiazoles and selenazoles. Ionradical organic chemistry principles and applications. References are incorporated into the text using the journal codes adopted by comprehensive heterocyclic chemistry, and are listed in full at the end of each. May, 2015 recent data on the synthesis of various selenoureas and selenium containing heterocycles derived therefrom have been systemized, analyzed, and generalized. The most significant and important result is that the p product is preferred, contrary to what happened for the dihydro5helicene with methyl substituents, and in agreement with experiment. Identification of a novel seleniumcontaining compound.
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